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ea0057005 | The effect of androgens on renal calcium and phosphate handling, independent of bone and in circumstances of low dietary calcium | BES2018

The effect of androgens on renal calcium and phosphate handling, independent of bone and in circumstances of low dietary calcium

Rougin Khalil , Ri Kim Na , Ferran Jardi , Frank Claessens , Dirk Vanderschueren , Brigitte Decallonne

Aims: We have previously shown that orchidectomy (ORX) in adult mice induces hypercalciuria and upregulation of renal Ca2+ and PO43− transporters, but also bone loss already after 2 weeks. Pretreatment with risedronate inhibited bone resorption and hypercalciuria but confirmed the upregulation of renal Ca2+ and PO43− transporters, suggesting bone-independent renal effects of androgens. We hypothesize...

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ea0071016 | Early effects of androgen deprivation on bone and mineral homeostasis in adult men: a prospective cohort study | BES2020

Early effects of androgen deprivation on bone and mineral homeostasis in adult men: A prospective cohort study

Rougin Khalil , Leen Antonio , R. Laurent Michael , Karel David , Ri Kim Na , Pieter Evenepoel , Anton Eisenhauer , Alexander Heuser , Etienne Cavalier , Sundeep Khosla , Frank Claessens , Dirk Vanderschueren , Brigitte Decallonne

Objective: Long-term androgen deprivation therapy (ADT) negatively influences bone. The short-term effects on bone and mineral homeostasis are less known. Therefore, we aimed to investigate the early effects of ADT on calcium/phosphate homeostasis and bone turnover.Design: Prospective cohort study.Methods: Eugonadal adult male sex offenders, who were referred for ADT to the endocrine outpatient clinic, received cyproterone acetate....

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Endocrine Abstracts

The effect of androgens on renal calcium and phosphate handling, independent of bone and in circumstances of low dietary calcium

Early effects of androgen deprivation on bone and mineral homeostasis in adult men: A prospective cohort study

BiosciAbstracts